CD147 monoclonal antibody attenuates abdominal aortic aneurysm formation in angiotensin II-Infused apoE-/- mice
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ABSTRACT:
ORGANISM(S): Mus <genus>
SUBMITTER: 
Cheng Xu
PROVIDER: PXD036063 | iProX | Mon Aug 15 00:00:00 BST 2022
REPOSITORIES: iProX
Publications
CD147 monoclonal antibody attenuates abdominal aortic aneurysm formation in angiotensin II-Infused apoE<sup>-/-</sup> mice.
Xu Cheng C Liu Xiaowei X Yu Lei L Fang Xiaoxin X Yao Lei L Lau HuiChong H Vyas Punit P Pryke Luke L Xu Baohui B Tang Lijiang L Jiang Jianjun J Chen Xiaofeng X
International immunopharmacology 20230630
<h4>Background</h4>Abdominal aortic aneurysm (AAA) is a life threatening vascular disease. Our previous study reported the upregulation of CD147 expression in human aortic aneurysms.<h4>Objective</h4>In this study, we injected apoE-/- mice intraperitoneally with CD147 monoclonal antibody or IgG control antibody to observe its effect on Angiotensin II (AngII) induced AAA formation.<h4>Methods</h4>ApoE-/- mice were randomly divided into an AngⅡ+CD147 antibody group (n = 20) and an AngⅡ+IgG antibod ...[more]
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