Translation control by maternal Nanog promotes oocyte maturation and early embryonic development
Ontology highlight
ABSTRACT:
ORGANISM(S): Danio Rerio
SUBMITTER: 
Yonghua Sun
PROVIDER: PXD036250 | iProX | Wed Aug 24 00:00:00 BST 2022
REPOSITORIES: iProX
Publications
Translational control by maternal Nanog promotes oogenesis and early embryonic development.
He Mudan M Jiao Shengbo S Zhang Ru R Ye Ding D Wang Houpeng H Sun Yonghua Y
Development (Cambridge, England) 20221219 24
Many maternal mRNAs are translationally repressed during oocyte development and spatio-temporally activated during early embryogenesis, which is crucial for oocyte and early embryo development. By analyzing maternal mutants of nanog (Mnanog) in zebrafish, we demonstrated that Nanog tightly controls translation of maternal mRNA during oogenesis via transcriptional repression of eukaryotic translation elongation factor 1 alpha 1, like 2 (eef1a1l2). Loss of maternal Nanog led to defects of egg matu ...[more]
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