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Label-free serum proteome in the rabbit CAS provocation model

ABSTRACT: A rabbit CAS provocation model was established to screen potential diagnostic biomarkers using quantitative serum proteomics

ORGANISM(S): Oryctolagus Cuniculus

SUBMITTER: Liliang Li

PROVIDER: PXD036383 | iProX | Mon Aug 29 00:00:00 BST 2022

REPOSITORIES: iProX

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Serum SELENBP1 and VCL Are Effective Biomarkers for Clinical and Forensic Diagnosis of Coronary Artery Spasm.

Lin Xinyi X Lin Zijie Z Zhao Xin X Liu Zheng Z Xu Chenchao C Yu Bokang B Gao Pan P Wang Zhimin Z Ge Junbo J Shen Yiwen Y Li Liliang L

International journal of molecular sciences 20221031 21

Coronary artery spasm (CAS) plays an important role in the pathogenesis of many ischemic heart entities; however, there are no established diagnostic biomarkers for CAS in clinical and forensic settings. This present study aimed to identify such serum biomarkers by establishing a rabbit CAS provocation model and integrating quantitative serum proteomics, parallel reaction monitoring/mass spectrometry-based targeted proteomics, and partial least-squares discriminant analysis (PLS-DA). Our results ...[more]

PMID: 36362053

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