Browse
Submit Data
Databases
API
Help

Dataset Information

Proteotypic differences of follicular-patterned thyroid neoplasms

ABSTRACT: The diagnosis of follicular-patterned thyroid tumors such as follicular adenoma (FA), follicular thyroid carcinoma (FTC), and follicular variant of papillary thyroid carcinoma (FvPTC) remains challenging. This study aimed to explore the molecular differences among these three thyroid tumors by proteomic analysis.

ORGANISM(S): Homo Sapiens

SUBMITTER: Tiannan Guo

PROVIDER: PXD036553 | iProX | Wed Sep 07 00:00:00 BST 2022

REPOSITORIES: iProX

ACCESS DATA

Json Xml

Publications

Proteotypic Differences of Follicular-Patterned Thyroid Neoplasms.

Huang Dongdong D Zhang Huifang H Li Lu L Ge Weigang W Liu Wei W Dong Zhen Z Gao Jinlong J Yao Nan N Fu Wenxin W Huang Lingling L Guo Tiannan T Sun Yaoting Y Teng Xiaodong X

Frontiers in endocrinology 20220706

The diagnosis of follicular-patterned thyroid tumors such as follicular thyroid adenoma (FA), follicular thyroid carcinoma (FTC), and follicular variant of papillary thyroid carcinoma (FvPTC) remains challenging. This study aimed to explore the molecular differences among these three thyroid tumors by proteomic analysis. A pressure cycling technology (PCT)-data-independent acquisition (DIA) mass spectrometry workflow was employed to investigate protein alterations in 52 formalin-fixed paraffin-e ...[more]

PMID: 35923625

Similar Datasets

Proteomics of thyroid tumours - Proteomics of thyroid tumours provides new insights into their molecular composition and changes associated with malignancy

Project description:Although most thyroid tumours are benign, thyroid cancer represents the most common malignancy of the endocrine system, comprising mainly follicular and papillary thyroid carcinomas (FTC and PTC, respectively). Previous studies have shed some light on the molecular pathogenesis of thyroid cancer but there have not been any comprehensive mass spectrometry-based proteomic studies to reveal protein expression differences between thyroid tumours and the molecular alterations associated with tumour malignancy. We applied a label-free quantitative mass spectrometry analysis to compare normal thyroid tissue with the three most common tumours of the thyroid gland: follicular adenoma, follicular carcinoma and papillary carcinoma.

2017-05-03 | PXD002732 | Pride

Comprehensive proteomics analysis to distinguish follicular adenoma and follicular thyroid carcinoma from indeterminate thyroid nodules.Comprehensive proteomics analysis to distinguish follicular adenoma and follicular thyroid carcinoma from indeterminate thyroid nodules

Project description:In this study, a total of 202 formalin fixed paraffin embedded (FFPE) thyroid tissues including 62 of benign nodules, 72 of follicular adenoma, and 68 of follicular thyroid carcinoma were used for the analyses. Here, through global FFPE proteomic analysis, proteins differentially expressed by group were identified and quantitative analysis was performed by LC-MS/MS.

2025-10-13 | PXD043154 | Pride

Human thyroid neoplasms LC-MS/MS analysis

Project description:The study aimes to evaluate the neoplasm proteomic changes in benign follicular adenoma versus malignant follicular variant of papillary thyroid carcinoma. Tumor and non-tumor adjacent samples were analyzed by liquid nano-chromatography mass spectrometry and protein abundance was evaluated by label free quantification.

2016-08-08 | PXD004322 | Pride

RNA sequencing data of follicular adenoma, widely invasive follicular thyroid carcinoma and atypical thyroid cancer

Project description:This study aimed to investigate the distinct molecular characteristics of atypical thyroid cancer in comparison to follicular adenoma and widely invasive follicular thyroid carcinoma (wiFTC). Tumor tissues from three patients with atypical thyroid cancer were collected during the same surgical period, alongside control samples from three individuals diagnosed with either follicular adenoma or wiFTC. All RNA samples used for downstream transcriptomic analysis had RNA integrity numbers (RIN) greater than 7.0, ensuring high-quality input for sequencing.

2026-05-20 | E-MTAB-15264 | biostudies-arrayexpress

Transcription profiling of human benign and malignant thyroid follicular neoplasi

Project description:Differentiation between Follicular Thyroid Carcinoma and Follicular Thyroid Adenoma based on their genetic signature

2005-01-01 | E-MEXP-97 | biostudies-arrayexpress

A comprehensive mass spectral library for human thyroid tissues

Project description:Thyroid nodules occur in about 60% of the population. Current diagnostic strategies, however, often fail at distinguishing malignant nodules before surgery, thus leading to unnecessary, invasive treatments. As proteins are involved in all physio/pathological processes, a proteome investigation of biopsied nodules may help correctly classify and identify malignant nodules and discover therapeutic targets. Quantitative mass spectrometry data-independent acquisition (DIA) enables highly reproducible and rapid throughput investigation of proteomes. An exhaustive spectral library of thyroid nodules is essential for DIA yet still unavailable. This study presents a comprehensive thyroid spectral library covering five types of thyroid tissue: multinodular goiter, follicular adenoma, follicular and papillary thyroid carcinoma, and normal thyroid tissue. Our library includes 925,330 transition groups, 157,548 peptide precursors, 121,960 peptides, 9941 protein groups, and 9826 proteins from proteotypic peptides. This library resource was evaluated using three papillary thyroid carcinoma samples and their corresponding adjacent normal thyroid tissue, leading to effective quantification of up to 7863 proteins from biopsy-level thyroid tissues.

2022-05-20 | PXD026395 | Pride

miRNA expression in Follicular Thyroid Adenomas and Carcinoma

Project description:The experiment was performed to identify differentially expressed microRNAs in follicular thyroid carcinoma and adenoma vs. normal thyroid tissue to explore possible common features in the proliferation stages. Furthermore comparisons between the carcinoma and adenoma were performed to search for distinct microRNAs that could be used in a classification model.

2011-11-30 | E-MTAB-736 | biostudies-arrayexpress

Transcription profiling of human thyroid gland cells to find molecular signatures of thyroid follicular neoplasia

Project description:Sixty-nine (69) tumor samples were collected from patients who underwent thyroidectomy.<br><br>The tumors included 22 benign follicular adenomas, 18 follicular carcinomas, 12 samples of microfollicular adenomas, 4 anaplastic carcinomas, 2 papillary carcinomas, and 9 nodular goiters. 23 samples were obtained from the expression profile repository, Array Express, these counted 14 papillary carcinomas and 9 normal thyroid.

2010-08-05 | E-MEXP-2442 | biostudies-arrayexpress

Transcription profiling of human thyroid follicular adenomas and thyroid papillary carcinomas to discriminate benign and malignant tumors

Project description:Identification of a stable gene expression signature with high classifying potential to discriminate benign (Follicular adenomas) and malignant (papillary carcinomas) thyroid tumors

2010-08-01 | E-MEXP-2335 | biostudies-arrayexpress

Comparison of gene expression between follicular thyroid adenoma and follicular thyroid carcinoma

Project description:Follicular thyroid tumours were investigated using global gene expression analysis. Aim of this study was the identification of new markers for follicular thyroid carcinoma. Keywords: cell type comparison Gene expression analysis of 4 follicular thyroid adenomas, 4 follicular thyroid carcinomas, and 4 microinvasive follicular thyroid carcinomas.

2009-02-27 | E-GEOD-15045 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data