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Impact of ATP on the enzymatic acetylation mediated by acetyltransferases PatZ and Yhbs acetylated peptides

ABSTRACT: 24 polypeptides (21 amino acids long) were synthesized and mixed as a substrate library. Then, these substrates were acetylated by E.coli acetyltransferase PatZ and Yhbs.

ORGANISM(S): Escherichia Coli

SUBMITTER: Tong Liu

PROVIDER: PXD036855 | iProX | Tue Sep 20 00:00:00 BST 2022

REPOSITORIES: iProX

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The synthesized peptides were acetlated by seven acetyltransferases from E.coli

Project description:24 polypeptides (21 amino acids long) were synthesized and mixed as a substrate library. Then, these substrates were acetylated by acetyl-CoA or seven E.coli acetyltransferase PatZ.

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Nonenzymatic acetylation of synthesized peptides

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Histones associated with downregulated genes are hypo-acetylated in Huntington’s disease models

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