Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Shan Cen
PROVIDER: PXD037068 | iProX | Wed Sep 28 00:00:00 BST 2022
REPOSITORIES: iProX
Guo Saisai S Lei Xiaobo X Chang Yan Y Zhao Jianyuan J Wang Jing J Dong Xiaojing X Liu Qian Q Zhang Zixiong Z Wang Lidan L Yi Dongrong D Ma Ling L Li Quanjie Q Zhang Yongxin Y Ding Jiwei J Liang Chen C Li Xiaoyu X Guo Fei F Wang Jianwei J Cen Shan S
Signal transduction and targeted therapy 20221227 1
The coronavirus disease 2019 (COVID-19) pandemic has devastated global health. Identifying key host factors essential for SARS-CoV-2 RNA replication is expected to unravel cellular targets for the development of broad-spectrum antiviral drugs which have been quested for the preparedness of future viral outbreaks. Here, we have identified host proteins that associate with nonstructural protein 12 (nsp12), the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 using a mass spectrometry (MS)-based p ...[more]