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Analysis of protein interaction between human platelets and SARS-CoV-2 envelope protein

ABSTRACT: Analysis of protein interaction between platelets and SARS-CoV-2 envelope protein

ORGANISM(S): Homo Sapiens Severe Acute Respiratory Syndrome Coronavirus 2

SUBMITTER: Chengde Yang

PROVIDER: PXD037073 | iProX | Tue Aug 08 00:00:00 BST 2023

REPOSITORIES: iProX

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CD36 mediates SARS-CoV-2-envelope-protein-induced platelet activation and thrombosis.

Tang Zihan Z Xu Yanyan Y Tan Yun Y Shi Hui H Jin Peipei P Li Yunqi Y Teng Jialin J Liu Honglei H Pan Haoyu H Hu Qiongyi Q Cheng Xiaobing X Ye Junna J Su Yutong Y Sun Yue Y Meng Jianfen J Zhou Zhuochao Z Chi Huihui H Wang Xuefeng X Liu Junling J Lu Yong Y Liu Feng F Dai Jing J Yang Chengde C Chen Saijuan S Liu Tingting T

Nature communications 20230821 1

Aberrant coagulation and thrombosis are associated with severe COVID-19 post-SARS-CoV-2 infection, yet the underlying mechanism remains obscure. Here we show that serum levels of SARS-CoV-2 envelope (E) protein are associated with coagulation disorders of COVID-19 patients, and intravenous administration of the E protein is able to potentiate thrombosis in mice. Through protein pull-down and mass spectrometry, we find that CD36, a transmembrane glycoprotein, directly binds with E protein and med ...[more]

PMID: 37604832

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