Dataset Information
A liquid chromatography-tandem mass spectrometry analysis of endogenous TWIST1 immunoprecipitates in the LSCs from MLL-AF9+ AML mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Xiaotong Ma
PROVIDER: PXD037217 | iProX | Sun Oct 09 00:00:00 BST 2022
REPOSITORIES: iProX
Publications
Twist family BHLH transcription factor 1 is required for the maintenance of leukemia stem cell in MLL-AF9<sup>+</sup> acute myeloid leukemia.
Haematologica 20240101 1
Leukemia stem cells (LSC) are a rare population capable of limitless self-renewal and are responsible for the initiation, maintenance, and relapse of leukemia. Elucidation of the mechanisms underlying the regulation of LSC function could provide novel treatment strategies. Here, we show that TWIST1 is extremely highly expressed in the LSC of MLL-AF9+ acute myeloid leukemia (AML), and its upregulation is positively regulated by KDM4C in a H3K9me3 demethylation-dependent manner. We further demonst ...[more]
