Proteomics

Dataset Information

0

Screening human protein interacting with mGluR2


ABSTRACT: Through mass spectrometry to obtain a high-quality mGluR2 interactome, screened host factors interacting with mGluR2. The experiment was repeated three times.

ORGANISM(S): Homo Sapiens

SUBMITTER: Jinliang Wang  

PROVIDER: PXD037306 | iProX | Tue Oct 11 00:00:00 BST 2022

REPOSITORIES: iProX

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Publications

Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.

Wang Xinxin X   Wen Zhiyuan Z   Cao Huizhen H   Luo Jie J   Shuai Lei L   Wang Chong C   Ge Jinying J   Wang Xijun X   Bu Zhigao Z   Wang Jinliang J  

Journal of virology 20230213 2


Identification of bona fide functional receptors and elucidation of the mechanism of receptor-mediated virus entry are important to reveal targets for developing therapeutics against rabies virus (RABV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our previous studies suggest that metabotropic glutamate receptor subtype 2 (mGluR2) functions as an entry receptor for RABV <i>in vitro</i>, and is an important internalization factor for SARS-CoV-2 <i>in vitro</i> and <i>in vivo<  ...[more]

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