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Cold exposure peptidome of male

ABSTRACT: cold exposure alters peptidome in hippocampus ,hypothalamus and pituitary connected with microbiota in gut

ORGANISM(S): Mus Musculus

SUBMITTER: Chenxi Jia

PROVIDER: PXD037471 | iProX | Mon Oct 17 00:00:00 BST 2022

REPOSITORIES: iProX

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Cold Exposure-induced Alterations in the Brain Peptidome and Gut Microbiome Are Linked to Energy Homeostasis in Mice.

Wang Xue X Wang Qianqian Q Zhao Mingxin M Xu Ying Y Fu Bin B Zhang Li L Wu Shuai S Yang Danfeng D Jia Chenxi C

Molecular & cellular proteomics : MCP 20230304 4

Energy homeostasis of mammals during cold exposure involves complicated neural regulation and is affected by gut microbiota. However, the regulatory mechanism remains unclear partially due to a lack of comprehensive knowledge of the signaling molecules involved. Herein, we performed region-resolvable quantitative profiling of the brain peptidome using cold-exposed mouse models and interrogated the interaction between gut microbes and brain peptides in response to cold. Region-specific alteration ...[more]

PMID: 36871861

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