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Potential blood biomarkers for chronic traumatic encephalopathy: the multi-omics landscape of an observational cohort

ABSTRACT: The present research recruited 4 pairs of gender- and age-matched rmTBI patients with healthy subjects. Their blood samples were collected for exosome isolation, multi-omics screening and low-throughput verification to explore potential diagnostic biomarkers in blood and its exosomes.

ORGANISM(S): Homo Sapiens

SUBMITTER: Xintong Ge

PROVIDER: PXD037637 | iProX | Fri Oct 21 00:00:00 BST 2022

REPOSITORIES: iProX

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Potential blood biomarkers for chronic traumatic encephalopathy: The multi-omics landscape of an observational cohort.

Ge Xintong X Guo Mengtian M Li Meimei M Zhang Shishuang S Qiang Junlian J Zhu Luoyun L Cheng Lu L Li Wenzhu W Wang Yan Y Yu Jinwen J Yin Zhenyu Z Chen Fanglian F Tong Wen W Lei Ping P

Frontiers in aging neuroscience 20221107

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts, which is susceptible in elderly people with declined mobility, athletes of full contact sports, military personnel and victims of domestic violence. It has been pathologically diagnosed in brain donors with a history of repetitive mild traumatic brain injury (rmTBI), but cannot be clinically diagnosed for a long time. By the continuous efforts by neuropathologists, neurologi ...[more]

PMID: 36420308

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