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Jorunnamycin treated bladder cancer for proteomics sequencing

ABSTRACT: Jorunnamycin inhibited bladder cancer through blocking cell migration, restraining proliferation and inducing apoptosis.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yong Xia

PROVIDER: PXD037638 | iProX | Thu Oct 20 00:00:00 BST 2022

REPOSITORIES: iProX

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Integrated multi-omics analyses reveal Jorunnamycin A as a novel suppressor for muscle-invasive bladder cancer by targeting FASN and TOP1.

Chen Ruijiao R Hao Xiaopeng X Chen Jingyuan J Zhang Changyue C Fan Huixia H Lian Fuming F Chen Xiaochuan X Wang Chao C Xia Yong Y

Journal of translational medicine 20230816 1

<h4>Background</h4>Bladder cancer is a urological carcinoma with high incidence, among which muscle invasive bladder cancer (MIBC) is a malignant carcinoma with high mortality. There is an urgent need to develop new drugs with low toxicity and high efficiency for MIBC because existing medication has defects, such as high toxicity, poor efficacy, and side effects. Jorunnamycin A (JorA), a natural marine compound, has been found to have a high efficiency anticancer effect, but its anticancer funct ...[more]

PMID: 37587470

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J82 human bladder cell line treated with frankincense oil

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