SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation

ABSTRACT: SENP1 deSUMOylates RIPK1 in TNF-R1 signaling complex (TNF-RSC), keeping RIPK1 in check. Loss of SENP1 leads to SUMOylation of RIPK1, which re-orchestrates TNF-RSC and modulates the ubiquitination patterns and activity of RIPK1.

ORGANISM(S): Mus Musculus

SUBMITTER: Daichao Xu  

PROVIDER: PXD037648 | iProX | Mon Oct 24 00:00:00 BST 2022

REPOSITORIES: iProX