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The pathogenic mechanism of ciprofloxacin in aortic aneurysm

ABSTRACT: The proteomics changes of VSMCs after CIP stimulation

ORGANISM(S): Homo Sapiens

SUBMITTER: Jianqiang Wu

PROVIDER: PXD037691 | iProX | Tue Oct 25 00:00:00 BST 2022

REPOSITORIES: iProX

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Investigation of the Pathogenic Mechanism of Ciprofloxacin in Aortic Aneurysm and Dissection by an Integrated Proteomics and Network Pharmacology Strategy.

Chen Zhaoran Z Wu Jianqiang J Wang Wei W Tang Xiaoyue X Zhou Lei L Lv Yanze Y Zheng Yuehong Y

Journal of clinical medicine 20230206 4

Aortic aneurysm and dissection (AAD) is a life-threatening disease worldwide. Recently, fluoroquinolones have been reported to significantly increase the risk of AAD. This study aimed to investigate the potential functional mechanism and molecular targets of fluoroquinolones in relation to AAD by an integrated proteomic and network pharmacology strategy. A total of 1351 differentially expressed proteins were identified in human aortic vascular smooth muscle cells (VSMCs) after ciprofloxacin (CIP ...[more]

PMID: 36835806

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