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MS data of phosphorylation sites of IRF4/TCF3/TCF4 by p38α

ABSTRACT: To identify putative phosphorylation sites on TCF3 (E47), TCF4, and IRF4, in vitro kinase assays were performed using recombinant MKK6E (a p38α activator) and p38α as kinases, and TCF3(E47), TCF4, or IRF4 proteins as substrates, the phosphorylation sites were analyzed by mass spectrometry (MS).

ORGANISM(S): Mus Musculus

SUBMITTER: Jiahuai Han

PROVIDER: PXD037718 | iProX | Wed Oct 26 00:00:00 BST 2022

REPOSITORIES: iProX

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A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation.

Wu Jianfeng J Yang Kang K Cai Shaowei S Zhang Xiaohan X Hu Lichen L Lin Fanjia F Wu Su-Qin SQ Xiao Changchun C Liu Wen-Hsien WH Han Jiahuai J

Nature communications 20221128 1

Plasma cells (PC) are antibody-secreting cells and terminal effectors in humoral responses. PCs differentiate directly from activated B cells in response to T cell-independent (TI) antigens or from germinal center B (GCB) cells in T cell-dependent (TD) antigen-induced humoral responses, both of which pathways are essentially regulated by the transcription factor BLIMP1. The p38 mitogen-activated protein kinase isoforms have already been implicated in B cell development, but the precise role of p ...[more]

PMID: 36443297

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