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Citrullinated proteins in platelets and platelets releasing microparticles may serve as a potential target of ACPA

ABSTRACT: To investigate the expression of peptidylarginine deiminase (PAD) enzymes and mining citrullination proteins in human platelets and platelets releasing microparticles (PRMs), and to determine whether these less-studied platelets associated citrullination proteins can be targeted by anti-citrullinated protein antibodies (ACPA) in RA.

ORGANISM(S): Homo Sapiens

SUBMITTER: Hui Geng

PROVIDER: PXD037743 | iProX | Wed Oct 26 00:00:00 BST 2022

REPOSITORIES: iProX

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Platelets derived citrullinated proteins and microparticles are potential autoantibodies ACPA targets in RA patients.

Xu Minjie M Du Rong R Xing Wenping W Chen Xueting X Wan Jian J Wang Shengqing S Xiong Li L Nandakumar Kutty Selva KS Holmdahl Rikard R Geng Hui H

Frontiers in immunology 20230124

Citrullinated neoepitopes have emerged as key triggers of autoantibodies anti-citrullinated protein antibodies (ACPA) synthesis in rheumatoid arthritis (RA) patients. Apart from their critical role in homeostasis and thrombosis, platelets have a significant contribution to inflammation as well. Although anuclear in nature, platelets have an intricate post-translational modification machinery. Till now, citrullination in platelets and its contribution to trigger autoantibodies ACPA production in ...[more]

PMID: 36761728

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