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The protein binding with diabetes induced circulation associated circular RNA of db/db mouse heart detected by label free LC-MSMS

ABSTRACT: The protein binding with diabetes induced circulation associated circular RNA (DICAR) pf db/db mouse compared with wild type

ORGANISM(S): Mus Musculus

SUBMITTER: Chunxiang Zhang

PROVIDER: PXD037745 | iProX | Thu Oct 27 00:00:00 BST 2022

REPOSITORIES: iProX

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CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes.

Yuan Qiong Q Sun Yunwei Y Yang Fan F Yan Dan D Shen Meihua M Jin Zhigang Z Zhan Lin L Liu Guangqi G Yang Ling L Zhou Qianyi Q Yu Zhijun Z Zhou Xiangyu X Yu Yang Y Xu Yong Y Wu Qingming Q Luo Jianfang J Hu Xiamin X Zhang Chunxiang C

Signal transduction and targeted therapy 20230308 1

In this study, we identified that a conserved circular RNA (circRNA) DICAR, which was downregulated in diabetic mouse hearts. DICAR had an inhibitory effect on diabetic cardiomyopathy (DCM), as the spontaneous cardiac dysfunction, cardiac cell hypertrophy, and cardiac fibrosis occurred in DICAR deficiency (DICAR<sup>+/-</sup>) mice, whereas the DCM was alleviated in DICAR-overexpressed DICAR<sup>Tg</sup> mice. At the cellular level, we found that overexpression of DICAR inhibited, but knockdown ...[more]

PMID: 36882410

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2014-09-15 | E-GEOD-54154 | biostudies-arrayexpress

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Project description:Diabetes Heart Study

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