Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Yu Ren
PROVIDER: PXD037869 | iProX | Tue Nov 01 00:00:00 GMT 2022
REPOSITORIES: iProX
Li Yatian Y Gao Zhenyue Z Wang Yuhong Y Pang Bo B Zhang Binbin B Hu Ruxin R Wang Yuqing Y Liu Chao C Zhang Xuebin X Yang Jingxuan J Mei Mei M Wang Yongzhi Y Zhou Xuan X Li Min M Ren Yu Y
Nature communications 20230710 1
Temozolomide (TMZ) therapy offers minimal clinical benefits in patients with glioblastoma multiforme (GBM) with high EGFR activity, underscoring the need for effective combination therapy. Here, we show that tonicity-responsive enhancer binding protein (NFAT5) lysine methylation, is a determinant of TMZ response. Mechanistically, EGFR activation induces phosphorylated EZH2 (Ser21) binding and triggers NFAT5 methylation at K668. Methylation prevents NFAT5 cytoplasm interaction with E3 ligase TRAF ...[more]