Guinea pig myopia model ocular posterior pole
Ontology highlight
ABSTRACT:
ORGANISM(S): Cavia Porcellus
SUBMITTER: 
Yan Zhang
PROVIDER: PXD037872 | iProX | Tue Nov 01 00:00:00 GMT 2022
REPOSITORIES: iProX
Publications
Targeting the cochlin/SFRP1/CaMKII axis in the ocular posterior pole prevents the progression of nonpathologic myopia.
Geng Chao C Liu Siyi S Wang Jindan J Wang Sennan S Zhang Weiran W Rong Hua H Cao Yunshan Y Wang Shuqing S Li Zhiqing Z Zhang Yan Y
Communications biology 20230829 1
Myopia is a major public health issue. However, interventional modalities for nonpathologic myopia are limited due to its complicated pathogenesis and the lack of precise targets. Here, we show that in guinea pig form-deprived myopia (FDM) and lens-induced myopia (LIM) models, the early initiation, phenotypic correlation, and stable maintenance of cochlin protein upregulation at the interface between retinal photoreceptors and retinal pigment epithelium (RPE) is identified by a proteomic analysi ...[more]
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