Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: Xiangdong Sun
PROVIDER: PXD037878 | iProX | Tue Dec 06 00:00:00 GMT 2022
REPOSITORIES: iProX
Yao Shan S Xu Min-Dong MD Wang Ying Y Zhao Shen-Ting ST Wang Jin J Chen Gui-Fu GF Chen Wen-Bing WB Liu Jian J Huang Guo-Bin GB Sun Wen-Juan WJ Zhang Yan-Yan YY Hou Huan-Li HL Li Lei L Sun Xiang-Dong XD
Nature communications 20230209 1
Alterations in energy metabolism are associated with depression. However, the role of glycolysis in the pathogenesis of depression and the underlying molecular mechanisms remain unexplored. Through an unbiased proteomic screen coupled with biochemical verifications, we show that the levels of glycolysis and lactate dehydrogenase A (LDHA), a glycolytic enzyme that catalyzes L-lactate production, are reduced in the dorsomedial prefrontal cortex (dmPFC) of stress-susceptible mice in chronic social ...[more]