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Identification interactional proteins related with KDM4A-AS1-encoded peptides in HEK293T

ABSTRACT: This study was conducted by using Flag tag to IP proteins expressed with fusion small peptides encoding KDM4A-AS1 and identified by high resolution mass spectrometry.

ORGANISM(S): Homo Sapiens

SUBMITTER: Bo Zhou

PROVIDER: PXD038125 | iProX | Mon Nov 14 00:00:00 GMT 2022

REPOSITORIES: iProX

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Long noncoding RNAs with peptide-encoding potential identified in esophageal squamous cell carcinoma: KDM4A-AS1-encoded peptide weakens cancer cell viability and migratory capacity.

Zhou Bo B Wu Yuyang Y Cheng Pei P Wu Chengyong C

Molecular oncology 20230410 7

Currently, the knowledge of long noncoding RNA (lncRNA)-encoded peptides is quite lacking in esophageal squamous cell carcinoma (ESCC). In this study, we simultaneously identified six lncRNA open reading frames (ORFs) with peptide-coding abilities including lysine-specific demethylase 4A antisense RNA 1 (KDM4A-AS1) ORF by combining weighted gene co-expression network analysis (WGCNA) for ESCC clinical samples, ribosome footprints, ORF prediction, mass spectrometry (MS) identification, and wester ...[more]

PMID: 36965032

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