Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Chun Zhang
PROVIDER: PXD038169 | iProX | Tue Nov 15 00:00:00 GMT 2022
REPOSITORIES: iProX
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20230501 5
Glomerulosclerosis is one of the major histopathologic changes in diabetic kidney diseases (DKD), which is characterized by excessive deposition of extracellular matrix (ECM) in the glomerulus mainly produced by mesangial cells in response to transforming growth factor-β (TGF-β) stimuli under diabetic conditions. Despite TGF-β has been implicated as a major pathogenic factor in the development of diabetic glomerulosclerosis, clinical trials of monoclonal antibodies against TGF-β failed to demons ...[more]