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Discovering sORF-encoded Peptides Associated with Secondary Metabolism in Streptomyces

ABSTRACT: To investigate the effect of small peptides up to 100aa on the regulation of secondary metabolite synthesis during the fermentation of this strain S187. Differential expression of peptides within 100aa at different growth time points of strain S187.

ORGANISM(S): Streptomyces

SUBMITTER: Chun Su

PROVIDER: PXD038189 | iProX | Thu Nov 17 00:00:00 GMT 2022

REPOSITORIES: iProX

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Multi-integrated approach for unraveling small open reading frames potentially associated with secondary metabolism in <i>Streptomyces</i>.

Fan Si-Min S-M Li Ze-Qi Z-Q Zhang Shi-Zhe S-Z Chen Liang-Yu L-Y Wei Xi-Ying X-Y Liang Jian J Zhao Xin-Qing X-Q Su Chun C

mSystems 20230915 5

<h4>Importance</h4>Due to their small size and special chemical features, small open reading frame (smORF)-encoding peptides (SEPs) are often neglected. However, they may play critical roles in regulating gene expression, enzyme activity, and metabolite production. Studies on bacterial microproteins have mainly focused on pathogenic bacteria, which are importance to systematically investigate SEPs in streptomycetes and are rich sources of bioactive secondary metabolites. Our study is the first t ...[more]

PMID: 37712700

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| PRJNA480907 | ENA

Project description:secondary metabolite

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