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TMT proteomics analysis of cerebrospinal fluid from patients with cerebral venous sinus thrombosis

ABSTRACT: In the present study, we detected the alterations of the CSF protein spectrum of CVST patients by TMT technique, screen differentially expressed proteins, analyze the functions of these signals through bioinformatics methods, and finally validate the key molecules through parallel reaction monitoring (PRM) technique.

ORGANISM(S): Homo Sapiens

SUBMITTER: Qiujing Wang

PROVIDER: PXD038259 | iProX | Tue Nov 22 00:00:00 GMT 2022

REPOSITORIES: iProX

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TMT proteomics analysis of cerebrospinal fluid from patients with cerebral venous sinus thrombosis.

Liu Yaqi Y Ding Rui R Li Meng M Ou Weiyang W Zhang Xifang X Yang Weijie W Huang Xiaofei X Chai Huihui H Wang Qiujing Q

Journal of proteomics 20230113

CVST is a type of venous stroke that mainly affects young adults with no reliable diagnostic markers and effective treatment strategies for secondary pathologies. However, the underlying pathological molecular mechanisms remain unclear. Here, we systematically analyzed the molecule profiling of the cerebrospinal fluid (CSF) in CVST patients via tandem mass tag (TMT)-based proteomics for the first time, aiming to reveal the pathogenesis and provide evidence for the diagnosis and treatment of CVST ...[more]

PMID: 36646273

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