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OTU7B modulates the mosquito immune response to Beauveria bassiana infection via deubiquitination of the Toll adaptor TRAF4

ABSTRACT: Insects use innate immunity to defend microbial infection. Toll pathway is a major immune signaling pathway that is associated with antifungal immune response in mosquitoes. Our study identified a fungal-induced deubiquitinase, OTU7B, which, when knocked out, promotes the translocation of the NF-κB factor Rel1 into the nucleus and confers enhanced resistance to fungal infection. We further found the counterpart of OTU7B, TRAF4, which is a component of Toll pathway and acts as an adaptor protein.

ORGANISM(S): Aedes Aegypti

SUBMITTER: Zhen Zou

PROVIDER: PXD038261 | iProX | Tue Nov 22 00:00:00 GMT 2022

REPOSITORIES: iProX

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OTU7B Modulates the Mosquito Immune Response to Beauveria bassiana Infection via Deubiquitination of the Toll Adaptor TRAF4.

Wang Yanhong Y Chang Mengmeng M Wang Mao M Ji Yannan Y Sun Xiaomei X Raikhel Alexander S AS Zou Zhen Z

Microbiology spectrum 20221220 1

The Aedes aegypti mosquito transmits devastating flaviviruses, such as Zika, dengue, and yellow fever viruses. For more effective control of the vector, the pathogenicity of Beauveria bassiana, a fungus commonly used for biological control of pest insects, may be enhanced based on in-depth knowledge of molecular interactions between the pathogen and its host. Here, we identified a mechanism employed by B. bassiana, which efficiently blocks the Ae. aegypti antifungal immune response by a protease ...[more]

PMID: 36537797

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