Quantitative proteomics profilling of p62 droplet
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens Rattus Norvegicus
SUBMITTER: 
Ping Xu
PROVIDER: PXD038262 | iProX | Fri Jun 09 00:00:00 BST 2023
REPOSITORIES: iProX
Publications
Local membrane source gathering by p62 body drives autophagosome formation.
Feng Xuezhao X Sun Daxiao D Li Yanchang Y Zhang Jinpei J Liu Shiyu S Zhang Dachuan D Zheng Jingxiang J Xi Qing Q Liang Haisha H Zhao Wenkang W Li Ying Y Xu Mengbo M He Jiayu J Liu Tong T Hasim Ayshamgul A Ma Meisheng M Xu Ping P Mi Na N
Nature communications 20231113 1
Autophagosomes are double-membrane vesicles generated intracellularly to encapsulate substrates for lysosomal degradation during autophagy. Phase separated p62 body plays pivotal roles during autophagosome formation, however, the underlying mechanisms are still not fully understood. Here we describe a spatial membrane gathering mode by which p62 body functions in autophagosome formation. Mass spectrometry-based proteomics reveals significant enrichment of vesicle trafficking components within p6 ...[more]
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