Proteomics

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Exploration on the Mechanism of Decreased Quality of Aging Oocytes After Ovulation

ABSTRACT: Decreased oocyte developmental potential is an important factor affecting fertility and embryonic development. Increasingly evidence is suggested that the decline in oocyte quality caused by aging after in vitro ovulation is a limiting factor affecting the development of assisted reproductive technologies in humans. However, the key molecular mechanisms underlying the decline in the quality of post-ovulatory aging (postOA) oocytes have not been fully characterized. Here, we obtained the protein profile and transcript profile of in vitro postOA oocytes. Particularly, we found the differential protein enrichment feature, such as RNA decay and chromosome segregation pathway. Moreover, transcriptomics analysis shows that down-regulated transcripts are increased in postOA oocytes in humans and mice. The mRNA-decapping enzyme 1A (DCP1A) as a key factor, influences the abundance of oocyte specific expressed marker protein Y-box-binding protein (YBX2), which leads to instability of maternal mRNA and more prone to de

ORGANISM(S): Mus Musculus

SUBMITTER: Teng Zhang  

PROVIDER: PXD038293 | iProX | Wed Nov 23 00:00:00 GMT 2022

REPOSITORIES: iProX

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Multi-omics revealed that DCP1A and SPDL1 determine embryogenesis defects in postovulatory ageing oocytes.

Kong Li L   Gong Yutian Y   Wang Yongyong Y   Yuan Mengjiao M   Liu Wenxiang W   Zhou Heyang H   Meng Xiangyue X   Guo Xinru X   Liu Yongbin Y   Zhou Yang Y   Zhang Teng T  

Cell proliferation 20241204 3

Growing evidence indicates that the deterioration of egg quality caused by postovulatory ageing significantly hampers embryonic development. However, the molecular mechanisms by which postovulatory ageing leads to a decline in oocyte quality have not been fully characterized. In this study, we observed an accelerated decay of maternal mRNAs through RNA-seq analyses in postovulatory-aged (PostOA) oocytes. We noted that these downregulated mRNAs should be degraded during the 2-cell stage. Proteomi  ...[more]

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