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XAF1 promotes the innate immune response against RNA viruses by regulating chromatin accessibility

ABSTRACT: The raw data of mass spectrometry in this article including MAVS-Turbo ID, XAF1 phosphorylation site and XAF1 interacting protein in nuclear

ORGANISM(S): Homo Sapiens

SUBMITTER: Fuping You

PROVIDER: PXD038540 | iProX | Mon Dec 05 00:00:00 GMT 2022

REPOSITORIES: iProX

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XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.

Kuang Ming M Zhao Yingchi Y Yu Haitao H Li Siji S Liu Tianyi T Chen Luoying L Chen Jingxuan J Luo Yujie Y Guo Xuefei X Wei Xuemei X Li Yunfei Y Zhang Zeming Z Wang Dandan D You Fuping F

Science advances 20230818 33

A rapid induction of antiviral genes is critical for eliminating viruses, which requires activated transcription factors and opened chromatins to initiate transcription. However, it remains elusive how the accessibility of specific chromatin is regulated during infection. Here, we found that XAF1 functioned as an epigenetic regulator that liberated repressed chromatin after infection. Upon RNA virus infection, MAVS recruited XAF1 and TBK1. TBK1 phosphorylated XAF1 at serine-252 and promoted its ...[more]

PMID: 37595039

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