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IRF1 acetylation sites by KAT8

ABSTRACT: Aim to identify the IRF1 acetylation site by KAT8 in cotransfected HEK293T cells

ORGANISM(S): Homo Sapiens

SUBMITTER: Yuanzhong Wu

PROVIDER: PXD038568 | iProX | Mon Dec 05 00:00:00 GMT 2022

REPOSITORIES: iProX

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Disrupting the phase separation of KAT8-IRF1 diminishes PD-L1 expression and promotes antitumor immunity.

Wu Yuanzhong Y Zhou Liwen L Zou Yezi Y Zhang Yijun Y Zhang Meifang M Xu Liping L Zheng Lisi L He Wenting W Yu Kuai K Li Ting T Zhang Xia X Chen Zhenxuan Z Zhang Ruhua R Zhou Penghui P Zhang Nu N Zheng Limin L Kang Tiebang T

Nature cancer 20230309 3

Immunotherapies targeting the PD-1/PD-L1 axis have become first-line treatments in multiple cancers. However, only a limited subset of individuals achieves durable benefits because of the elusive mechanisms regulating PD-1/PD-L1. Here, we report that in cells exposed to interferon-γ (IFNγ), KAT8 undergoes phase separation with induced IRF1 and forms biomolecular condensates to upregulate PD-L1. Multivalency from both the specific and promiscuous interactions between IRF1 and KAT8 is required for ...[more]

PMID: 36894639

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