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Aeromonas hydrophila CobQ is a new type of NAD+/Zn2+ independent protein lysine deacetylase in prokaryote

ABSTRACT: Protein NƐ-lysine acetylation (Kac) modification plays crucial roles on diverse physiological and pathological functions in cell.

ORGANISM(S): Aeromonas Hydrophila Subsp. Hydrophila Atcc 7966

SUBMITTER: Xiangmin Lin

PROVIDER: PXD038735 | iProX | Fri Dec 09 00:00:00 GMT 2022

REPOSITORIES: iProX

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Aeromonas hydrophila CobQ is a new type of NAD+- and Zn2+-independent protein lysine deacetylase.

Wang Yuqian Y Wang Guibin G Zhang Lishan L Cai Qilan Q Lin Meizhen M Huang Dongping D Xie Yuyue Y Lin Wenxiong W Lin Xiangmin X

eLife 20250225

Protein NƐ-lysine acetylation (Kac) modifications play crucial roles in diverse physiological and pathological functions in cells. In prokaryotic cells, there are only two types of lysine deacetylases (KDACs) that are Zn2+- or NAD+-dependent. In this study, we reported a protein, AhCobQ, in Aeromonas hydrophila ATCC 7966 that presents NAD+- and Zn2+-independent KDAC activity. Furthermore, its KDAC activity is located in an unidentifie ...[more]

PMID: 39998869

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