Dataset Information
Allocryptopine alleviates IBD through modulating gut microbiota and inhibiting Cx3cl1-Cx3cr1 axis/NF-κB/apoptosis in DSS-induced mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Yisong Liu
PROVIDER: PXD038736 | iProX | Mon Dec 12 00:00:00 GMT 2022
REPOSITORIES: iProX
Publications
Anti-Inflammatory Effects of Allocryptopine via the Target on the CX3CL1-CX3CR1 axis/GNB5/AKT/NF-κB/Apoptosis in Dextran Sulfate-Induced Mice.
Biomedicines 20230205 2
Allocryptopine (ALL) is an isoquinoline alkaloid extracted from <i>Macleaya cordata</i><b>(Willd). R. Br.</b>, which has been claimed to have anti-inflammatory and neuroprotection properties. However, the mechanism by which ALL ameliorates inflammatory bowel disease (IBD) remains unclear. Here, we used network pharmacology and quantitative proteomic approaches to investigate the effect of ALL on IBD pathogenesis. Network pharmacology predicted potential targets and signaling pathways of ALL's an ...[more]
