Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Ge Bai
PROVIDER: PXD038754 | iProX | Tue Dec 13 00:00:00 GMT 2022
REPOSITORIES: iProX
Cui Qinqin Q Bi Hongyun H Lv Zhanyun Z Wu Qigui Q Hua Jianfeng J Gu Bokai B Huo Chanjuan C Tang Mingmin M Chen Yanqin Y Chen Chongjiu C Chen Sihan S Zhang Xinrui X Wu Zhangrui Z Lao Zhengkai Z Sheng Nengyin N Shen Chengyong C Zhang Yongdeng Y Wu Zhi-Ying ZY Jin Zhigang Z Yang Peiguo P Liu Huaqing H Li Jinsong J Bai Ge G
Cell 20230203 4
Complex diseases often involve the interplay between genetic and environmental factors. Charcot-Marie-Tooth type 2 neuropathies (CMT2) are a group of genetically heterogeneous disorders, in which similar peripheral neuropathology is inexplicably caused by various mutated genes. Their possible molecular links remain elusive. Here, we found that upon environmental stress, many CMT2-causing mutant proteins adopt similar properties by entering stress granules (SGs), where they aberrantly interact wi ...[more]