Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: Fanhua Wei
PROVIDER: PXD038885 | iProX | Mon Dec 19 00:00:00 GMT 2022
REPOSITORIES: iProX
Li Haoning H Zhang Yuying Y Li Chengye C Ning Peng P Sun Hailiang H Wei Fanhua F
Frontiers in microbiology 20230112
Progranulin (PGRN) plays an important role in influenza virus infection. To gain insight into the potential molecular mechanisms by which PGRN regulates influenza viral replication, proteomic analyzes of whole mouse lung tissue from wild-type (WT) versus (<i>vs</i>) PGRN knockout (KO) mice were performed to identify proteins regulated by the absence vs. presence of PGRN. Our results revealed that PGRN regulated the differential expression of ALOX15, CD14, CD5L, and FCER1g, etc., and also affecte ...[more]