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Combine in silico target fishing, Comparative proteomics analysis and in vitro assays to identify antibacterial effects of a TCM (the leaves of Strobilanthes cusia Kuntze) against the Penicillin resistant Streptococcus pneumoniae

ABSTRACT: The anti-bacterial mechanism of the leaves of Strobilanthes cusia Kuntze against the Penicillin-resistant Streptococcus pneumoniae were analyzed by the comparative proteomics

ORGANISM(S): Streptococcus Pneumoniae 23f

SUBMITTER: Depo Yang

PROVIDER: PXD038886 | iProX | Sun Dec 18 00:00:00 GMT 2022

REPOSITORIES: iProX

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Combining the In Silico and In Vitro Assays to Identify Strobilanthes cusia Kuntze Bioactives against Penicillin-Resistant Streptococcus pneumoniae.

Han Xiaoyu X Jin Lu L Zhao Zhimin Z Xu Xinjun X Liu Shiyi S Huang Yuquan Y Liu Xiaoli X Xu Yuehong Y Yang Depo D Huang Wei W Wang Li L

Pharmaceuticals (Basel, Switzerland) 20230110 1

Leaves of Strobilanthes cusia Kuntze (S. cusia) are a widely used alexipharmic Traditional Chinese Medicine (TCM) in southern China for the prevention of cold and respiratory tract infectious diseases. One of the most common bacterial pathogens in the respiratory tract is the gram-positive bacterium Streptococcus pneumoniae. The antibiotic resistance of colonized S. pneumoniae makes it a more serious threat to public health. In this study, the leaves of S. cusia</i ...[more]

PMID: 36678602

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