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Integrative Proteogenomic Characterization of Early Esophageal Cancer

ABSTRACT: A comprehensive proteogenomic analysis of 786 trace-tumor-samples from 154 esophageal cancers, covering all 9 major histopathology stages and 22 substages via pathological dissection.

ORGANISM(S): Homo Sapiens

SUBMITTER: Chen Ding

PROVIDER: PXD038961 | iProX | Tue Dec 20 00:00:00 GMT 2022

REPOSITORIES: iProX

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Integrative proteogenomic characterization of early esophageal cancer.

Li Lingling L Jiang Dongxian D Zhang Qiao Q Liu Hui H Xu Fujiang F Guo Chunmei C Qin Zhaoyu Z Wang Haixing H Feng Jinwen J Liu Yang Y Chen Weijie W Zhang Xue X Bai Lin L Tian Sha S Tan Subei S Xu Chen C Song Qi Q Liu Yalan Y Zhong Yunshi Y Chen Tianyin T Zhou Pinghong P Zhao Jian-Yuan JY Hou Yingyong Y Ding Chen C

Nature communications 20230325 1

Esophageal squamous cell carcinoma (ESCC) is malignant while the carcinogenesis is still unclear. Here, we perform a comprehensive multi-omics analysis of 786 trace-tumor-samples from 154 ESCC patients, covering 9 histopathological stages and 3 phases. Proteogenomics elucidates cancer-driving waves in ESCC progression, and reveals the molecular characterization of alcohol drinking habit associated signatures. We discover chromosome 3q gain functions in the transmit from nontumor to intraepitheli ...[more]

PMID: 36966136

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