FOXA1 O-GlcNAcylation-mediated transcriptional switch governs metastasis capacity in breast cancer

ABSTRACT: The forkhead protein FOXA1 has been found to play a critical role in orchestrating hormonal-signaling network and to function as a pioneer factor to regulate breast-specific gene expression,However, whether interplay between O-GlcNAcylation and FOXA1 affects the genome-wide transcriptional activity of this TF and subsequently orchestrates downstream gene expression networks in breast cancer progression needs further elucidation.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yubo Liu  

PROVIDER: PXD039019 | iProX | Wed Dec 21 00:00:00 GMT 2022

REPOSITORIES: iProX