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FOXA1 O-GlcNAcylation-mediated transcriptional switch governs metastasis capacity in breast cancer

ABSTRACT: The forkhead protein FOXA1 has been found to play a critical role in orchestrating hormonal-signaling network and to function as a pioneer factor to regulate breast-specific gene expression,However, whether interplay between O-GlcNAcylation and FOXA1 affects the genome-wide transcriptional activity of this TF and subsequently orchestrates downstream gene expression networks in breast cancer progression needs further elucidation.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yubo Liu

PROVIDER: PXD039019 | iProX | Wed Dec 21 00:00:00 GMT 2022

REPOSITORIES: iProX

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FOXA1 O-GlcNAcylation-mediated transcriptional switch governs metastasis capacity in breast cancer.

Liu Yajie Y Yu Kairan K Kong Xiaotian X Zhang Keren K Wang Lingyan L Zhang Nana N Chen Qiushi Q Niu Mingshan M Li Wenli W Zhong Xiaomin X Wu Sijin S Zhang Jianing J Liu Yubo Y

Science advances 20230818 33

FOXA1, a transcription factor involved in epigenetic reprogramming, is crucial for breast cancer progression. However, the mechanisms by which FOXA1 achieves its oncogenic functions remain elusive. Here, we demonstrate that the O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) of FOXA1 promotes breast cancer metastasis by orchestrating the transcription of numerous metastasis regulators. O-GlcNAcylation at Thr432, Ser441, and Ser443 regulates t ...[more]

PMID: 37595040

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