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Orthopoxvirus evasion from TRIM5α-mediated restriction

ABSTRACT: AP-MS experiment to identify the target the interactome of TRIM5 and cyclophilin A during vaccinia virus infection.

ORGANISM(S): Homo Sapiens Vaccinia Virus Wr

SUBMITTER: Geoffrey L. Smith

PROVIDER: PXD039094 | iProX | Thu Dec 22 00:00:00 GMT 2022

REPOSITORIES: iProX

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TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6.

Zhao Yiqi Y Lu Yongxu Y Richardson Samuel S Sreekumar Meghna M Albarnaz Jonas D JD Smith Geoffrey L GL

Nature 20230809 7975

Human tripartite motif protein 5α (TRIM5α) is a well-characterized restriction factor for some RNA viruses, including HIV<sup>1-5</sup>; however, reports are limited for DNA viruses<sup>6,7</sup>. Here we demonstrate that TRIM5α also restricts orthopoxviruses and, via its SPRY domain, binds to the orthopoxvirus capsid protein L3 to diminish virus replication and activate innate immunity. In response, several orthopoxviruses, including vaccinia, rabbitpox, cowpox, monkeypox, camelpox and variola ...[more]

PMID: 37558876

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