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Proteomic analysis of cerebrospinal fluid exosomes derived from non-small cell lung cancer related leptomeningeal carcinomatosis

ABSTRACT: Comprehensive proteomic analysis of exosomes derived from cerebrospinal fluid of NSCLC patients with or without leptomeningeal carcinomatosis was demonstrated.

ORGANISM(S): Homo Sapiens

SUBMITTER: Hui Bu

PROVIDER: PXD039102 | iProX | Mon Dec 26 00:00:00 GMT 2022

REPOSITORIES: iProX

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Cerebrospinal fluid exosomal protein alterations via proteomic analysis of NSCLC with leptomeningeal carcinomatosis.

Hou Lan L Chen Xin X Qiu Gang G Qi Xuejiao X Zou Yueli Y He Junying J Bu Hui H

Journal of neuro-oncology 20230901 2

<h4>Purpose</h4>Leptomeningeal carcinomatosis (LC) is a rare complication of non-small cell lung cancer (NSCLC) with highly mortality. Cerebrospinal fluid (CSF) as a special kind of tumor microenvironment (TME) better represents alterations than plasma. However, the clinical value of protein profiles of exosome in CSF as liquid biopsy remains unclear.<h4>Methods</h4>In this study, CSF samples of NSCLC patients with (LC group) or without (NSCLC group) LC were collected and compared to patients wi ...[more]

PMID: 37656377

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