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SIRT3 acts as delactylase to suppress hepatocellular carcinoma development

ABSTRACT: Our integrative studies characterized SIRT3 as a delactylase to suppress HCC development, and the activation of SIRT3 might be a promising therapeutic mean for HCC.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yi Wang

PROVIDER: PXD039202 | iProX | Tue Jan 03 00:00:00 GMT 2023

REPOSITORIES: iProX

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SIRT3-dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth.

Jin Jing J Jin Jing J Bai Lin L Wang Dongyao D Ding Wei W Cao Zhuoxian Z Yan Peidong P Li Yunjia Y Xi Lulu L Wang Yuxin Y Zheng Xiaohu X Wei Haiming H Ding Chen C Wang Yi Y

EMBO reports 20230310 5

Lysine lactylation (Kla) is a recently discovered histone mark derived from metabolic lactate. The NAD<sup>+</sup> -dependent deacetylase SIRT3, which can also catalyze removal of the lactyl moiety from lysine, is expressed at low levels in hepatocellular carcinoma (HCC) and has been suggested to be an HCC tumor suppressor. Here we report that SIRT3 can delactylate non-histone proteins and suppress HCC development. Using SILAC-based quantitative proteomics, we identify cyclin E2 (CCNE2) as one o ...[more]

PMID: 36896611

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