Dataset Information

Proteomics of Mus musculus liver infected with Clonorchis sinensis

ABSTRACT: The molecular mechanism at the early infection of Clonorchis sinensis

ORGANISM(S): Mus Musculus

SUBMITTER: Zeli Tang

PROVIDER: PXD039310 | iProX | Sat Jan 07 00:00:00 GMT 2023

REPOSITORIES: iProX

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Publications

Multilayer omics reveals the molecular mechanism of early infection of Clonorchis sinensis juvenile.

Wu Yuhong Y Deng Xueling X Wu Zhanshuai Z Liu Dengyu D Fu Xiaoyin X Tang Lili L He Shanshan S Lv Jiahui J Wang Jilong J Li Qing Q Zhan Tingzheng T Tang Zeli Z

Parasites & vectors 20230816 1

<h4>Background</h4>Clonorchiasis remains a non-negligible global zoonosis, causing serious socioeconomic burdens in endemic areas. Clonorchis sinensis infection typically elicits Th1/Th2 mixed immune responses during the course of biliary injury and periductal fibrosis. However, the molecular mechanism by which C. sinensis juvenile initially infects the host remains poorly understood.<h4>Methods</h4>The BALB/c mouse model was established to study early infection (within 7 days) with C. sinensis ...[more]

PMID: 37587524

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Project description:In this data set, we reported for the first time that huanglongbing disease (HLB) induces major changes in the expression of global genes in flavedo, vascular and juice vesicle tissues of citrus fruit. 68 Total samples were analyzed. cDNA generation, array analysis, and statistical tests were performed as a service at the Interdisciplinary Center for Biotechnology Research (ICBR) Microarray Core facility at the University of Florida (Gainesville, FL). The linear models were used for array analysis (Smyth GK et al. Bioinformatics, 2005, 2067-2075). The linear models were firstly used to assess differential expression, and then an empirical Bayes method was used to moderate the standard errors. 13 comparisons were performed for the study. The comparisons in Citrus sinensis cv. Hamlin included: SC vs. CC (genes that respond to infection in symptomatic vascular core); SJV vs. CJV (genes that respond to infection in symptomatic juice vesicle); SS vs. CS (genes that respond to infection in symptomatic seed); SP vs. CP (genes that respond to infection in symptomatic peel). The comparisons in Citrus sinensis cv. Valencia included: SP vs. HP (genes that respond to infection in symptomatic peel); ASP vs. HP (genes that respond to infection in asymptomatic peel); SP vs. ASP (genes that respond to infection in symptomatic peel compared to asymptomatic peel); SC vs. HC (genes that respond to infection in symptomatic vascular core); ASC vs. HC (genes that respond to infection in asymptomatic vascular core); SC vs. ASC (genes that respond to infection in symptomatic vascular core compared to asymptomatic vascular core); SJV vs. HJV (genes that respond to infection in symptomatic juice vesicle); ASJV vs. HJV (genes that respond to infection in asymptomatic juice vesicle); SJV vs. ASJV (genes that respond to infection in symptomatic juice vesicle compared to asymptomatic juice vesicle). ESTs with significant expression changes (P value <0.001; false discovery rate <0.01 with equal or higher than 2-fold changes in expression) were selected for further analysis.

Dataset Information

Proteomics of Mus musculus liver infected with Clonorchis sinensis

Publications

Multilayer omics reveals the molecular mechanism of early infection of Clonorchis sinensis juvenile.

Similar Datasets

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