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Age-, sex- and proximal–distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates

ABSTRACT: To determine the molecular landscape of large intestinal aging, we collected 104 pieces of fresh large intestinal tissue from 26 Macaca fascicularis and performed age-, location-, and sex-resolved multi-omics analyses, including transcriptomics, proteomics, phosphoproteomics and metabolomics.

ORGANISM(S): Macaca Fascicularis Fascicularis

SUBMITTER: Lunzhi Dai

PROVIDER: PXD039361 | iProX | Thu Jan 18 00:00:00 GMT 2024

REPOSITORIES: iProX

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Age-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

Wang Xinyuan X Luo Yaru Y He Siyu S Lu Ying Y Gong Yanqiu Y Gao Li L Mao Shengqiang S Liu Xiaohui X Jiang Na N Pu Qianlun Q Du Dan D Shu Yang Y Hai Shan S Li Shuangqing S Chen Hai-Ning HN Zhao Yi Y Xie Dan D Qi Shiqian S Lei Peng P Hu Hongbo H Xu Heng H Zhou Zong-Guang ZG Dong Biao B Zhang Huiyuan H Zhang Yan Y Dai Lunzhi L

Nature aging 20240206 3

The incidence of intestinal diseases increases with age, yet the mechanisms governing gut aging and its link to diseases, such as colorectal cancer (CRC), remain elusive. In this study, while considering age, sex and proximal-distal variations, we used a multi-omics approach in non-human primates (Macaca fascicularis) to shed light on the heterogeneity of intestinal aging and identify potential regulators of gut aging. We explored the roles of several regulators, including those from tryptophan ...[more]

PMID: 38321225

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Age-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

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