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Protein differential profiling of OTUB1 knockout osteoblasts

ABSTRACT: This project is to figure out the differential proteins in control and OTUB1 knockout osteoblast cells

ORGANISM(S): Mus Musculus

SUBMITTER: Lingqiang Zhang

PROVIDER: PXD039507 | iProX | Tue Jan 17 00:00:00 GMT 2023

REPOSITORIES: iProX

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OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2.

Zhu Qiong Q Fu Yesheng Y Cui Chun-Ping CP Ding Yi Y Deng Zhikang Z Ning Chao C Hu Fan F Qiu Chen C Yu Biyue B Zhou Xuemei X Yang Guan G Peng Jiang J Zou Weiguo W Liu Cui Hua CH Zhang Lingqiang L

Signal transduction and targeted therapy 20230407 1

Bone homeostasis is maintained by the balance between osteoblastic bone formation and osteoclastic bone resorption. Dysregulation of this process leads to multiple diseases, including osteoporosis. However, the underlying molecular mechanisms are not fully understood. Here, we show that the global and conditional osteoblast knockout of a deubiquitinase Otub1 result in low bone mass and poor bone strength due to defects in osteogenic differentiation and mineralization. Mechanistically, the stabil ...[more]

PMID: 37024477

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