Proteomics

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Phosphoproteomics reveals the disturb of kinase-substrates in intracerebral hemorrhage with hyperhomocysteinaemia

ABSTRACT: To elucidate the impact and mechanism of homocysteine on intracerebral hemorrhage at a system-wide level, we used a global phosphoproteomic approach combined with proteomics. Hyperhomocysteinaemia (HHcy) mice was induced by high methionine diet，and Experimental intracerebral hemorrhage was induced by injection of autologous blood. Perihematoma tissue was collected and MS/MS was performed to get phophoproteomics data.

ORGANISM(S): Mus Musculus

SUBMITTER: Zhouping Tang  

PROVIDER: PXD039748 | iProX | Tue Jan 31 00:00:00 GMT 2023

REPOSITORIES: iProX

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Publications

Homocysteine impedes neurite outgrowth recovery after intracerebral haemorrhage by downregulating pCAMK2A.

Guo Guangyu G   Yang Jingfei J   Guo Wenliang W   Deng Hong H   Yu Haihan H   Bai Shuang S   Li Gaigai G   Tang Yingxin Y   Zhang Ping P   Xu Yuming Y   Pan Chao C   Tang Zhouping Z  

Stroke and vascular neurology 20230228 4

Hyperhomocysteinemia (HHcy) is independently associated with poorer long-term prognosis in patients with intracerebral haemorrhage (ICH); however, the effect and mechanisms of HHcy on ICH are still unclear. Here, we evaluated neurite outgrowth and neurological functional recovery using simulated models of ICH with HHcy in vitro and in vivo. We found that the neurite outgrowth velocity and motor functional recovery in the ICH plus HHcy group were significantly slower than that in the control grou  ...[more]

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