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Longitudinal proteomic investigation of COVID-19 vaccination

ABSTRACT: 163 participants with paired peripheral blood mononuclear cells and serum samples，at D0, D28, day 57 (D57) by TMT-based proteomics

ORGANISM(S): Homo Sapiens

SUBMITTER: Tiannan Guo

PROVIDER: PXD039826 | iProX | Wed Sep 06 00:00:00 BST 2023

REPOSITORIES: iProX

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Longitudinal proteomic investigation of COVID-19 vaccination.

Wang Yingrui Y Zhu Qianru Q Sun Rui R Yi Xiao X Huang Lingling L Hu Yifan Y Ge Weigang W Gao Huanhuan H Ye Xinfu X Song Yu Y Shao Li L Li Yantao Y Li Jie J Guo Tiannan T Shi Junping J

Protein & cell 20230901 9

Although the development of COVID-19 vaccines has been a remarkable success, the heterogeneous individual antibody generation and decline over time are unknown and still hard to predict. In this study, blood samples were collected from 163 participants who next received two doses of an inactivated COVID-19 vaccine (CoronaVac®) at a 28-day interval. Using TMT-based proteomics, we identified 1,715 serum and 7,342 peripheral blood mononuclear cells (PBMCs) proteins. We proposed two sets of potentia ...[more]

PMID: 36930526

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