Modulation of Microbial Bile Acid Metabolism by DT-109 Ameliorates Nonalcoholic Steatohepatitis in Nonhuman Primates
Ontology highlight
ABSTRACT:
ORGANISM(S): Macaca Fascicularis Fascicularis
SUBMITTER: 
Rong Zeng
PROVIDER: PXD040009 | iProX | Fri Feb 10 00:00:00 GMT 2023
REPOSITORIES: iProX
Publications
DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates.
Qu Pengxiang P Rom Oren O Li Ke K Jia Linying L Gao Xiaojing X Liu Zhipeng Z Ding Shusi S Zhao Mingming M Wang Huiqing H Chen Shuangshuang S Xiong Xuelian X Zhao Ying Y Xue Chao C Zhao Yang Y Chu Chengshuang C Wen Bo B Finney Alexandra C AC Zheng Zuowen Z Cao Wenbin W Zhao Jinpeng J Bai Liang L Zhao Sihai S Sun Duxin D Zeng Rong R Lin Jiandie J Liu Wanqing W Zheng Lemin L Zhang Jifeng J Liu Enqi E Chen Y Eugene YE
Cell metabolism 20230410 5
Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysregulated glycine metabolism has emerged as a causative factor and therapeutic target in NASH. Here, we report that the tripeptide DT-109 (Gly-Gly-Leu) dose-dependently attenuates steatohepatitis and fibr ...[more]
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