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Proteins interacting with Lnc530 in mouse embryonic stem cells

ABSTRACT: The goal of this study is to identify the potential interaction proteins of Lnc530 in mouse embryonic stem cells.

ORGANISM(S): Mus Musculus

SUBMITTER: Ping Zheng

PROVIDER: PXD040075 | iProX | Sun Feb 12 00:00:00 GMT 2023

REPOSITORIES: iProX

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Long noncoding RNA Lnc530 localizes on R-loops and regulates R-loop formation and genomic stability in mouse embryonic stem cells.

Gong Daohua D Wang Lin L Zhou Hu H Gao Jing J Zhang Weidao W Zheng Ping P

Stem cell reports 20230316 4

Embryonic stem cells (ESCs) are superior to differentiated cells to maintain genome stability, but the underlying mechanisms remain largely elusive. R-loops are constantly formed during transcription and are inducers of DNA damage if not resolved. Here we report that mouse ESCs (mESCs) can efficiently prevent unscheduled R-loop formation, and a long noncoding RNA Lnc530 plays regulatory role. Lnc530 is expressed in mESCs and localizes on R-loops. Depletion of Lnc530 in mESCs causes R-loop accumu ...[more]

PMID: 36931280

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