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Proteomics analysis of the myocardium form chronic hypobaric hypoxia-induced mice model

ABSTRACT: C57BL/6J mice were assigned to the hypobaric hypoxia chamber for simulation of high-altitude conditions. iTRAQ proteomics analysis/nanoUHPLC-MS/MS analysis was performed accordingly in the right myocardium of mice that had been allowed to develop hypoxia-induced pulmonary hypertension after hypobaric hypoxia exposure.

ORGANISM(S): Mus Sp.

SUBMITTER: Jie Yang

PROVIDER: PXD040342 | iProX | Thu Feb 23 00:00:00 GMT 2023

REPOSITORIES: iProX

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Mitochondria-associated membrane protein PACS2 maintains right cardiac function in hypobaric hypoxia.

Yang Jie J Sun Mengjia M Chen Renzheng R Ye Xiaowei X Wu Boji B Liu Zhen Z Zhang Jihang J Gao Xubin X Cheng Ran R He Chunyan C He Jingyu J Wang Xuhong X Huang Lan L

iScience 20230305 4

Hypobaric hypoxia (HH) is the primary challenge at highland. Prolonged HH exposure impairs right cardiac function. Mitochondria-associated membrane (MAM) plays a principal role in regulating mitochondrial function under hypoxia, but the mechanism was unclear. In this study, proteomics analysis identified that PACS2, a key protein in MAM, and mitophagy were downregulated in HH. Metabolomics analysis indicated suppression of glucose and fatty acids aerobic oxidation in HH conditions. Cardiomyocyte ...[more]

PMID: 36968068

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Hypoxic pulmonary hypertension study

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