Ontology highlight
ABSTRACT:
ORGANISM(S): Candida Albicans
SUBMITTER: Guanghua Huang
PROVIDER: PXD040559 | iProX | Fri Mar 03 00:00:00 GMT 2023
REPOSITORIES: iProX
Guan Guobo G Tao Li L Li Chao C Xu Ming M Liu Ling L Bennett Richard J RJ Huang Guanghua G
Nature communications 20230412 1
The human fungal pathogen Candida albicans can switch stochastically and heritably between a "white" phase and an "opaque" phase. Opaque cells are the mating-competent form of the species, whereas white cells are thought to be essentially "sterile". Here, we report that glucose depletion, a common nutrient stress, enables C. albicans white cells to undergo efficient sexual mating. The relative expression levels of pheromone-sensing and mating-associated genes (including STE2/3, MFA1, MFα1, FIG1, ...[more]