Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Xiaobo Yu
PROVIDER: PXD040603 | iProX | Mon Mar 06 00:00:00 GMT 2023
REPOSITORIES: iProX
Xu Meng M Xu Kaikun K Yin Shangqi S Chang Cheng C Sun Wei W Wang Guibin G Zhang Kai K Mu Jinsong J Wu Miantao M Xing Baocai B Zhang Xiaomei X Han Jinyu J Zhao Xiaohang X Wang Yajie Y Xu Danke D Yu Xiaobo X
Molecular & cellular proteomics : MCP 20230519 7
Hepatocellular carcinoma (HCC) is a prevalent cancer in China, with chronic hepatitis B (CHB) and liver cirrhosis (LC) being high-risk factors for developing HCC. Here, we determined the serum proteomes (762 proteins) of 125 healthy controls and Hepatitis B virus-infected CHB, LC, and HCC patients and constructed the first cancerous trajectory of liver diseases. The results not only reveal that the majority of altered biological processes were involved in the hallmarks of cancer (inflammation, m ...[more]