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Identification of a peptide encoded by lncRNA BVES-AS1 as an oncogenic factor in colorectal cancer via the SRC/mTOR signaling pathway

ABSTRACT: This study was conducted by using Flag tag to IP proteins expressed with fusion small peptides encoding BVES-AS1 and identified by high resolution mass spectrometry.

ORGANISM(S): Homo Sapiens

SUBMITTER: Weiwei Zheng

PROVIDER: PXD040608 | iProX | Mon Mar 06 00:00:00 GMT 2023

REPOSITORIES: iProX

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Peptide encoded by lncRNA BVES-AS1 promotes cell viability, migration, and invasion in colorectal cancer cells via the SRC/mTOR signaling pathway.

Zheng Weiwei W Guo Yingchang Y Zhang Guangtan G Bai Junwei J Song Yucheng Y Song Xiaofei X Zhu Qinhui Q Bao Xuebin X Wu Gang G Zhang Chao C

PloS one 20230622 6

Long non-coding RNAs (lncRNAs) have been revealed to harbor open reading frames (ORFs) that can be translated into small peptides. The peptides may participate in the pathogenesis of colorectal cancer (CRC). Herein, we investigated the role of a lncRNA BVES-AS1-encoded peptide in colorectal tumorigenesis. Through bioinformatic analysis, lncRNA BVES-AS1 was predicted to have encoding potential and to be associated with poor prognosis of patients with CRC. In CRC cells, BVES-AS1 was validated to e ...[more]

PMID: 37347740

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